Lee Women’s Hospital launched fourth-generation IVF to help elder couples' dreams finally come true

What is the fourth-generation IVF?
The so-called fourth-generation IVF is based on the “third-generation PGS (preimplantation genetic screening)”, combining with the valued up to million dollars “embryo image time-lapse monitoring system”“ and using the latest algorithm with the data base accumulated for more than of clinical experience ofinfertility to score individual embryos, select the best quality embryos for implantation, and finally increase the success rate to the highest!


The third-generation PGS (pre-implantation genetic screening) mainly solves the problem of embryoic chromosomal abnormalities caused by the advanced age of the parents, and this technique could also apply to the case of multiple failed IVF and multiple miscarriages. Lee Women’s Hospital uses the highest resolution “Next Generation Sequencing Analysis Platform (NGS)”, which can exclude more than 60,000 abnormal genes which would cause diseases such as Down's syndrome.

Combining with the artificial intelligence system, the AI, the“embryo image time-lapse monitoring system”, it became the so-called 3.5 generation IVF. This machine can continuously observe for more than 120 hours without taking out the embryo from the culture dish. Besides, a special identification chip is installed in the embryo's culture dish, which can automatically read and store the patient's embryo data as well as isolatepollutions, creatinga six-star culturing environment! At the same time, the microscope in the monitoring system would take pictures of the embryos every 10 minutes, and every single embryo will have more than 10,000 images to completely record the development process of the embryo.

Finally, the “latest algorithm” developed exclusively developed by Lee Women’s Hospital is used to accurately calculate and analyze the enormous amount of the data, that is, to select the best embryo after scoring them according to the data, so that the pregnancy rate will be 3 times more than that of the ordinary embryo. The overall pregnancy rate has increased to more than 70%, and the miscarriage rate has dropped to 5%, which makes it to be the last hope for the infertile elder women to have children. We call it the latest 4th-generation IVF.



So far, this technology had helped many elder parents. Take the 38-year-old Mrs. S as an example, who has always wanted to have a child since the age of 30 so she has tried several traditional Chinese medicine in the past 8 years, which cost her 100,000 dollars to buy expensive medicine but in vain. Until a year and a half ago, she decided to use the 4th-generation IVF, after the doctor isolated 20 high-quality eggs and formed embryos into 4 high-grade blastocysts, and then chose the best one for implantation. Fortunately, she was pregnant in the end and gave birth to a 3,000 grams of healthy baby boy in April this year. She hopes to have a second child in the following year.

Another example is Mrs. W,who failed to be pregnant within 4 years of her marriage, she was introduced to the Lee Women’s Hospital by her friend when she was nearly 40. After inspection, she found that her egg’s quality had dropped sharply due to her advanced age. After 9 eggs were taken out within 3 treatments, 4 better embryos were chosen to make the IVF, after the scoring, the best one was selected for implantation.Fortunately, the pregnancy was successfully achieved in only one treatment course! It took only 9 months for Miss W from getting pregnant to giving birth to a 2,800-gram brother and sister this summer.


The success rate of the embryos selected through the AI system are three times higher than the normal embryos, and the miscarriage rate is significantly reduced from an average of 20% to 5%, and the overall pregnancy rate is increased to more than 70%! This is good news for infertile parents, women at advanced maternal age, and people with genetic diseases! Our paper has been accepted by the internationally renowned reproductive medicine journal RBMO and published in the “European Society of Human Reproduction and Embryology”. It has also been highly praised by reproductive medicine experts in nearly 80 countries! The world's leading “4th-generation AI IVF” will ignite a glimmer of hope for women at advanced maternal age.