Knowledge Sharing

2011.09.13

Comparison of live births after frozen versus fresh blastocyst transfer

Annual Meeting of Taiwanese Society for Reproductive Medicine,Abstract
Comparison of live births after frozen versus fresh blastocyst transfer

HUANG JUN-JIA*1,2, CHEN XIU-HUI 1, Zhong- Yi Chen 1, Tsung-Hsien Lee 4, HUANG LI-XIANG 1,3,Maw-Sheng Lee1,4
1 Division of Infertility Clinic, Lee Women’s Hospital, 2 Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, 3 Institute of Medicine, Chung Shan Medical University, 4 Department of Obstetrics and Gynecology, Chung Shan Medical University

The aim of this study is to investigate the live births after transfer of vitrified frozen or fresh blastocysts. From January 2009 to September 2010, a total of 181 and 424 embryo transfer was carried out from frozen and fresh embryos, respectively. Viability and pregnancy rate of frozen embryos was 100% (692/692) and 58.0% (105/181), respectively, whereas pregnancy rate of fresh embryos was 51.7% (219/424). The implantation rate was similar between two groups, i.e., 32.2% and 30.4% in the frozen and fresh group, respectively. Similar abortion rate was found in two groups, i.e., 16.2% and 16.9% in the frozen and fresh group, respectively. However, a higher proportion of lower gestational age and lower body weight were found in fetus derived from fresh (2423g, 36.0 weeks of gestation) than in those derived from frozen embryos (2463g, 36.6 weeks). Moreover, transfer with fresh embryos appears to be associated with a higher proportion of low body weigh live births. A sex ratio imbalance favoring male offspring was shown in transfer with fresh embryos (male-to-female ratio = 1.4:1 in fresh group, v.s, 1:1 in frozen group). Taken together, our results indicates in terms of live births, frozen embryos appear to be better candidates for blastocyst transfer as compared to fresh embryos.