Knowledge Sharing

2011.09.13

Clinical results of fluorescence in situ hybridization diagnosis of chromosome translocation in pre-implantation embryos

2011 Annual Meeting of Taiwanese Society for Reproductive Medicine, Poster
Clinical results of fluorescence in situ hybridization diagnosis of chromosome translocation in pre-implantation embryos

CAO HUI-MEI*1, BAI YI-PING 1, ZHENG EN-HUI 1, CHEN QIU-PING 1, HUANG JUN-JIA 1, Zhong- Yi Chen 1, Tsung-Hsien Lee 1,2,3, Maw-Sheng Lee 1,2,3
1 Division of Infertility Clinic, Lee Women’s Hospital, 2 Institute of Medicine, Chung Shan Medical University, 3 Department of Obstetrics and Gynecology, Chung Shan Medical University

Introduction:The aim of this study is to investigate the effect of pre-implantation embryo diagnosis on the delivery of healthy fetuses for patients with chromosome translocations.

Methods:Pre-implantation embryos were diagnosed with fluorescence in situ hybridization.

RESULTS:Of the 27 patients receiving embryo transfer, 9 got successful pregnancy. Among them, 7 delivered healthy babies, healthy fetus was prenatal diagnosed in another patient still in pregnancy, and abortion was resulted in only one patient.

Conclusion:Couples with chromosome translocation may benefit from pre-implantation diagnosis.