PGD Case: Prevention of hereditary hearing loss

Anna had experienced two miscarriages, both of which revealed genetic disorders during prenatal check-ups, leading to the difficult decision of termination. In their pursuit of having a healthy baby, the couple sought assistance from overseas doctors.

Mr. Leo mentioned why they ultimately decided to fly from the Philippines to Taiwan:" After conducting extensive research online, comparing hospitals in the United States and Taiwan, we chose to undergo IVF treatment at the renowned Lee Women's Hospital, known for its expertise in IVF. The hospital has achieved numerous successful cases, totaling tens of thousands."

After a diagnosis by Dr. Maw-Sheng Lee, the couple was advised to undergo CGT examination to determine the possibility of hidden genetic disorders. The results indicated that both individuals carried the SLC26A4 gene associated with hearing loss and the Pendred syndrome gene, which follows an autosomal recessive inheritance pattern. This meant that their baby would have a 1/4 chance of inheriting the disease. However, Lee Women's Hospital's laboratory could further screen and exclude embryos affected by the condition.

In order to conceive a healthy child, Dr. Maw-Sheng Lee recommended that they proceed with the IVF treatment and perform PGT-A (PGS) and PGT-M (PGD) testing on the embryos. They successfully identified healthy embryos free from hearing loss and achieved pregnancy after a single implantation.

Leo also shared during a seminar in Manila in March of this year:
"I would like to express my gratitude to Dr. Lee for providing me with encouragement and assisting us in successfully selecting healthy embryos through PGD testing, considering our genetic predisposition for hearing loss. Throughout the treatment, I encourage everyone to feel free to ask Dr. Lee any questions. Although the process was challenging, we gathered our courage, and now my wife is pregnant. We are truly grateful to Dr. Lee.

Please believe in yourselves and your ability to overcome these challenges. Due to our special trust in Lee Women's Hospital, we decided to fly here specifically for advanced prenatal ultrasound and fetal echocardiography to conduct a comprehensive examination for our baby."
 

PGT-A (PGS)	It can detect abnormalities in the number of chromosomes in embryos.
PGT-M (PGD)	It can identify whether embryos are affected by specific diseases or carry the genetic predisposition for those diseases.
Autosomal recessive inheritance	The baby will only be affected if they have a pair of specific disease genes. If both parents carry the genetic predisposition or are affected by the disease, there is a high probability that the baby will be affected.
CGT (Carrier Genetic Test)	It can detect the presence of multiple specific monogenic inherited disease carriers.

For inquiry, please contact: ivftaiwan@gmail.com